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Examples of observed isotropy are the CMB and the distribution of cosmological redshift of distant galaxies
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They are still working on CMB... last year potential WMAP catastrophy was highlighted...
http://arxiv.org/abs/0905.0075 ... and this year another has come
http://cdsweb.cern.ch/record/1238439?ln=ca
I'd be keen to see Wright's response...
This thread discusses as test where quasars don't fit, regarding cosmological distances implied by redshift.