As has been noted, if you want to keep pesticides out of the house then a vacuum cleaner (unless you are willing to capture and release outside).
A barrier spray of insecticide can be placed around the outside of your house at entrances, windows, gaps etc. If you were building new I would say spray between the walls (works great for many pests and lasts a long time in the dark dry spaces).
Spiders are generally very sensitive to synthetic pyrethroids (a class of chemistry)...
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