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At 43% you will definitely notice it visually, but it will also depend on what eyepiece you use. I have a Sigma mirror lens with about the same obstruction and it's not really fit for visual use because of this, yet takes fine photos.
The worst problem arises with low-power eyepieces that have a lot of spherical aberration of the exit pupil, which causes the "kidneybean" blackout. Some early Naglers had this issue, later ones don't.
Personally I'd be looking for a scope with a secondary obstruction ratio no higher than 33%, preferably lower.
The Intes Mak-Newtonians would be my pick in your case - fast focal ratio, a small secondary obstruction, and a closed tube.
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