I used to have a similar problem when using a DBK31 for guiding through a GPUSB, I could get it guiding no worries with 2sec exposures, it would guide away for hours without a single problem if I was imaging with a DSLR, but the minute I started an exposure with the QHY8, PHD would lock up instantly... First night I was guiding I took 10x10min subs of M42 with a DSLR, The very next night I attempted the same with the QHY8 and did not get a single frame.... Never figured out the problem... Tried a bunch of different software suites for both guiding and imaging... Once I got the QHY5, the problem mysteriously disappeared...
I find hardware problems like that to be the most difficult to troubleshoot, as if you're the only person having that problem, and the person writing the drivers/software can not replicate your problems (as was the case with my issue) they simply inform you that it must be a problem specific to your computer, and you're on your own...
Having said that, your DSI should have no troubles finding guide stars in 2sec exposures... What are you using as a guide scope?
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