I had a go at M42 on Wednesday night, as the moon out to the west ruined any hope of trying for my favorite, the Milky Way.
Settings on the 350D, 10 second exposure, 5.6 Av, ISO 1600, noise reduction 0n, lens 90-300mm at 300mm, shot in RAW mode and processed with RawShooter Essentials and Neat Image.
No tracking, just fixed on the tripod and hoped for the best focus.
Soon to have the EQ6 and ED80, so this will be a definate target for me to capture, and the Milky Way of course