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Peter - The 5D has a sensor 1.6x the size of the 20D or the QHY8 that you're used to... 35mm diagonal. And given that the focuser tube is 2" (50mm round) I dare say the inside of the focuser tube would clip the light cone somewhat. If you were to put a 3" FT focuser on it you may.. MAY get rid of the vignetting.. but I don't know that for sure obviously.
I will say though, with a chip the size of the KAF-8300, you do not need to worry about that. I did not take flats and did not notice any vignetting in the images..
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