I am certainly not an authority on this subject but the way I image is like this. One night I shoot my colour. I like lots of data in the colour (usually around 90-110 minutes in each colour). I then focus the remaining nights on getting luminence and Ha which are my detail components. I image from about 40 degrees up in all imaging components. My recent tarantula image took 3 nights to get all the data.
To get scope back into the same position each night I use a grid over the viewing panel of my guide star. I simply put the star into the same position and this affords me good registration.
Hope that helps and best of luck with mono imaging.
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