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I can think of 2 possible explanations, both would need you to narrow down the area to a region or crater related to it.
1) There are a half a dozen areas that are known to stand out under Earthshine (as there are those that positively shine under Full Moon).
2) the more interesting (but speculative) cause, Transit Lunar Phenomena (TLPs) (possibly the Lunar version of the UFO's that turn out to be swamp gas!). There are regions that have been known to intermittently glow, for no obvious reasons. I can't remember which areas, but I'm sure a web search would find something.
Regards
Glenn
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