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I image at 2300mm focal length (and guide at the same). I find around 3 seconds is the most frequent I want to send guide adjustments and using PHD I set RA aggressiveness down to 30% Hystersis up to 40%, resist DEC switching and this gives me around +/- 2 arc seconds drift to manage (near sub pixel for my location).
Other than that - balance your gear really, really well, tune and remove backlash as well as possible and understand seeing and bin your shots appropriately for your focal length, pixel size and well depth and quality of night skies / seeing conditions.
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