I recall the good old days when a group of us observed at the Paint Ball place at Kulnura - Iceman (Mike) had his 10" dob and Frogman (Anthony) had his 12" dob. I would often look at the same object side by side in those two scopes, and time and again, the 12" gave clearly brighter images.
If you are wanting to push the limits with dimmer deep sky objects, particularly faint galaxies, the 12 inch will be much better. If however you are doing the open cluster/planetary/moon caper, then the 10 inch will be more that enough to be well satisfied.
As others have said, portability is a huge difference. The 12 inch seems almost twice as big to handle. It is harder to fit into a car comfortably, but would be OK if just moving around the backyard etc. The 10 inch is easy to move around, very light and portable by comparison.
Good luck..whichever way you go you will have a wonderful time of discovery.
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