Dont try to combine before PS, load them seperately into PS as colour channels. NB needs more (different) adjustment than RGB in each channel, which is easier in PS.
Take Ha at bin 1, as many subs and the longest exposure time as you can get, and use it as the Lum channel (where all the detail and sharpness is) and less OIII,SII subs at bin 2 to increase data with less exposure time. The OIII and SII subs can be really crappy without affecting the final result, just blur them to hell to get rid of noise, detail is not important (well, to get started anyway).
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