For sure. That is exactly what I'm doing. I have one ED80 and one Celestron Newtonian 5". I swap the guider or imaging camera on both scopes. Here's a pic of my setup. If you can focus on the newt with your DSLR you'll have no problem focusing the QHY5
http://www.multiweb.com.au/astro/QHY8_piggyback.jpg