Hi Ben,
I've used both configurations - 80mm achro guide scope piggybacked on an ED80 as in my avatar, and a side by side plate for my current rig with 80mm guidescope on one side and 40D/lens on the other.
I prefer the side by side setup as I can fiddle with the guidescope without disturbing the imaging scope. I also found that because of the similar tube lenghts of the achro and ED80, the camera ended up under the upper scope's diagonal causing things to get a bit cramped!
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