When all else fails... it's worth checking on your PSU (Power Supply Unit) and eventually maybe your M/B(motherboard).
I've recently been through a similar situation.
First, USB's failed. Then all of a sudden began having troubles booting system up, then it got to the point where I couldn't read 1 of my HDDs, then neither would work.
I instantly thought it was HDD failure, all signs pointed to that.
But every check I ran in BIOS indicated my HDDs were still there.
But for voltage return checks, seemed as though that my HDDs weren't recieving nuff power to run.
So then I thought PSU was failing. Changed that out, fixed it for about 5 hrs, then the problems got worse.
It ended up being the M/B that was dying on me. And it was only that segment on the board, but it was enough for it to become a write-off.
So after buying a new M/B, new CPU, and a new PSU, I found out that my HDDs were fine, USB were working again, and I've now got a faster better computer than I had before.... *groan*... expensive exercise.
Hope you don't have a similar issue. But when things start failing regarding hardware, especially if BSOD's (Blue Screen of Death) comes up, then it's highly likely you're in for an upgrading episode.
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