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Evolution is very unpredictable, at the moment humanity has very little selection pressure on it. So we will see a great deal of genetic variation. If at some point we do see a selection event, say environmental then when will see some rather dramatic change. As others have said though you have to throw our tech into the mix, we will be tempted to have a fiddle ourselves.
100 millions years is a long time though, go back that amount and mammals were just coming to be. Alex is right most species only last around 5 million years, so odds are we will not be here. A more interesting question is how much change will we cope with before we consider ourselves a new species? If you met a Neanderthal on the street you might just think he was a stocky person, if you met Lucy well....
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