It's a shame to see the Shuttle go, but they obviously have some flaws and they're getting past their prime. When you have accidents like these it's time to move on. Human spaceflight is a tricky business I guess, if possible it would be better to simply send unmanned probes to do the work for us with no risk to human life if it explodes or something because a heat tile fell off.
Humans need to explore though and see with our own eyes