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Marc, the likely answer to your problem is to dither between subs. This is a commonly overlooked technique which can vastly improve the quality of the master. Alternatively, as Fred points out, you can chase it with the healing brush tool (this is a rather ghastly task IMO, but works) or use data rejection algorithms to your advantage. The latter assumes the outlier pixels are in different locations so the data rejection algorithm can detect the anomalies in each sub when you combine them - hence make sure you dither between subs!
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