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Well, being a CCD stack user, Poisson sigma reject may do it, but its aggressive and can leave artifacts. I found freehand draw and impute rejected pixels corse and a pain in the bum to get the settings right for anything other than obvious blooming, theres always a few bright pixels left over. Its always good to try and get rid of random stuff before deconvolution/sharpening, or artifacts just get rediculous, but after much stuffing around in CCD stack, PS healing really is the ducks guts, and gives the most control.
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