Oh, I'm sure these encounters are "big" enough to do that.
"Streamers..." as in "the Magellanic Stream...???"
Obviously the outcome is dependent on a number of factors relating to the interaction (not JUST how "big"). Relative angles, distance, motion, mass, etc. Also depends to some extent on how you define "galaxy" and "intergalactic space". I expect the Magellanic Stream may lie somewhere in-between (for example).