Deep space photography with a DSLR on a 12", will be tonnes more difficult than on an ED80 - because of the focal length and weight involved.
At long focal lengths, guiding, focus, seeing, collimation all become more critical and make it more difficult to get good images.
Start with the ED80 on your EQ6 - but you'll still need a separate guidescope. I have mine side by side mounted. I posted some pictures of my setup about a month ago.
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