[avandonk]

My role totally was to run the lab with $3 million worth of equipment. I collected and did the prelimanary analysis of the data to make sure it was of the highest quality. It is hard enough to solve a structure with good data and impossible with even mediocre data. I won't bore you with all the complexities.

Ok here is the complexity. Each spot intensity we measure gives us a magnitude of one of the many vectors of the three dimensional Fourier Transform of the molecule,we do not know the 'Phase' or direction of these magnitudes. We use heavy metal derivatives or other even more subtle methods to bootstrap into a solution. The really nice thing is with good data the solution is unique!

Bert