A while back, I posted a pick NGC1365 that was a nightmare to proccess. It was an LRGB image useing LBVR photometry filters (dont have RGB on this scope). These filters are not ideal for RGB due to a wide overlapping frequency response, so I thought the difficulty in processing was due to these attributes.
After someone else also had difficulty processing pics off the scope, an investigation found the B (blue) and V (visual) filters were reversed uuuuggggggggg, hours of frustration for nothing.
Here is the same pic with B and V in the right spots
http://fredsastro.googlepages.com/NG...full;init:.jpg
No problem processing now, and there I was with a thousand theorys on the problem, goes to show how carefull you have to be with set up, with just about every aspect of an imaging scope, one extra hr checking at the beginning saves 10 hrs of crap later ;-).