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I have come across problems with the Prolific USB/serial device before. In that it just does not seem to work on laptops without existing db9 ports.
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This statement is not correct for all machines or devices. I use a Prolific Serial/USB adapter for EQMOD on my Toshiba, and it has NO Serial ports, it's the only one that works properly. I tried using a belkin one for some time and it always hung at the start of the application. USB/Serial adapters are very hit and miss, you just have to test them before getting one that works. I tried atleast 5 different brands before settling on the Prolific one.