I have always taken darks at the same time as lights each session, to try and keep temps constant (helps with CCD temp readout on DSI) - this is with fairly short exposures though, once I get guiding and increase exposure times, I don't know how keen I'll be to snap 10-20 at 2-5min per dark each time!
Maybe choose some fairly standard exposure times, renew darks each full moon???
Also - from the manual of Nebulosity on taking dark frames -
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make sure that no light is getting to the camera (wrapping the front in tin foil is great for this – black plastic lenscaps are quite "clear" to near IR light).
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Don't know what difference this would make, and have not done this, but could be worth a try....
