I like it. The Tarantula is well centred and the off-centre LMC is contrasted nicely by the sparser areas at left. Nice. Looks sharp and not at all noisey at that size.
I don't think noise would be a problem at 10xISO400 with ICNR if you haven't adjusted the levels much. If you want us to see the noise you'll have to stretch it more and give us a closer look.
I reckon you're ready for a deeper shot with that excellent kit that you've got, say one where you go for 60 mins total exposure, oh, and a closer crop on the nebula.
Maybe frame the next one so that the LMC runs horizontal and you can get more stars in pic.
Just suggestions.
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