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Sorry misread the original. Yes if you rotate your camera when imaging then you may eliminate some of your dust motes. It would depending on how you combined them, but your mote shadows may not be considered as outlier pixels. It would depend on what they were lying on when rotated, both within the image and on glass surfaces. If they were on the filter or reducer optics then the motes would still appear in the same spot of the image no matter how you turned your camera.
It is very hard for vignetting not to be an issue. It can come from a number of sources, one that is outside the effects of shadowing by internal structures is light falloff (which technically isn't really vignetting which refers to shadowing). Unless your lense can produce a perfectly flat image then the area being illuminated by your lens/mirror will nearly always have an area of uneven illumination or light gradient of some sort. The best way to deal with this type of gradient is with a flat. You can sometimes remove it using an Antivignetting technique in Photoshop or similar, but doing this throws away information. It would be much better to remove as much of the the problem before you worked on it in PS
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