Nice shot.
The "spotlights" add something different to it, and are aimed perfectly at the focal point of the image, so I think they are good to keep (if you could successfully remove them).
I see the grain/noise you mention but it's not overwhelming. I think the ideal size for the JPG version is about 2/3 of the large version, just because of the slight noise, the level of sharpness, and the fact that the image is quite big to start with.
Interesting coloured rings caused by the "spotlight" on the left (lower), almost looks like a planetary nebula.
You've managed to get pretty good range of brightness - the glob not being overexposed and the faint nebulosity being present without significant noise. That's not easy.
