Strange, no answers yet from the locals. I'm sure they'll come.
Mike, I would think you drive to Wangaratta, then along the Great Alpine Road to Bright - 2 comfortable hours drive? Probably try and get accommodation in Bright. You'll be able to hire all you want in Bright - including chains for tyres. Then it's a 45 min drive up the wonders of Mt Buffalo.
http://www.ski.com.au/resorts/buffalo/
http://www.parkweb.vic.gov.au/1park_display.cfm