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Yes, though "usually" its the other way around - guide with the ED80 and image with the C11. BUT... there are no rules in this game. Considering you intend manually guiding with an illuminated reticle eyepiece, then guiding with the C11 seems logical considering the magnification of the guide star. In this configuration, the guiding tolerance of the C11 should ensure no trails when imaging through the ED80. With the ED80 you can image wide field nebulae, clusters etc and if seeing permits use the C11 instead (role swap).
Once you've got yourself a good GEM you can mount whatever OTA you choose. The Newt vs. SCT debate goes on for years. Both have their merits for visual and astrophotography.
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