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My understanding is that subtle variations in the distribution of energy in the early universe (WMAP, etc) lead to a honeycomb texture of variable densities, with the galaxies lined up along the "walls" with vast caverns of relatively empty space in between. The end result is a rough general orientation of the galaxies in lines and planes, and with a more general facing a particular direction than what you'd expect if the original distribution was completely random.
The short answer is I don't know.
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