Depends on where you live and where storage is locate in relation to observing, but almost certainly you would use a 10" more often than a 12".
The 12" is not only more hassle to lug around, but you also have longer wait for cooldown before you can use it. IMO/E the 12" is also more awkward to operate, and sit down at in comfort, due to its sheer bulk. I like to sit and "meditate" at the EP, stare at an object for a good while. Lot more easily done with the 10".
I recently sold my 12" GSO and bought a 10" Saxon aka Skywatcher. Much happier with it. The Saxon also came with Pyrex mirror which seems to do the job, because the scope is very usable after zero cooldown time (turn on fan just to blow off inversion layer) - but it's not winter yet. 10" GSO with all the extras is a great scope also.
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