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Hi David,
Artificial flat frames are sort of OK, but much better to take some real ones. I'll make an assumption here, so correct me if I'm wrong, but the camera to scope orientation can't really change. If you've got a standard T-adapter then that screws into the back of the scope, then bayonets into the camera. This makes it much easier to take flats as the cam to scope orientation can't change. You'll have to spend about five minutes one day to take some sky flats. There are many references to how to take them, even some here on IIS. If your camera orientation can move, put some reference marks on the adapter when you've got the cam in about the right position, then you can go back.
For the dust motes it doesn't really matter as they move with the sensor. But for the uneven illumination it matters. BTW I have an ED80 as well, the illumination from mine looks pretty much the same as yours, slightly off centre, so I wouldn't worry about it.
The flats should allow you to have an even light pollution gradient, which is much easier to correct out than the radial one you have now.
Cheers
Stuart
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