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To calculate pixel resolutions use this formula
(205 x Pixel size in microns) / Telescope focal length in mm.
Ideal resolution is between 2.5 arcseconds / pixel to 5, depending on seeing conditions.
Dennis is right about over sampling. And other disadvantage of over sampling is that exposure time has to increase. The amount of the light coming thru telescope will be spread over more pixels so it will take longer to fill the wells of those pixels. I think that effect will be same as if you increase f ratio of telescope.
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