Thanks for the responses.
The scope has a CYCK spider so I do not think that is the problem. For the record it also has a carbon fibre tube with CYCK focuser and a Sharpstar F4 coma corrector.
I re-collimated yesterday (with OCal). I am very inexperienced but my impression is that it works well with the least reliable aspect being the final primary mirror adjustment.
I then spent a lot of time last night faffing with the scope. Long story short I now believe the issue was primarily tilt combined with some poor collimation. I managed to dial these out and got to a nice clean image with very minimal tilt detected by ASIStudio. Pretty happy with that at about 2am. I then thought i was good to capture some data. I slewed to the target and rotated about 1.5 degrees - and image is crap again.
Frustrating but progress made. I will now concentrate on identifying movement in the image train.
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