Maybe update iTunes to the latest version. Although Windows 10 has a direct connection to your iPhone via USB to lightning cable and iTunes is not even used, updating iTunes may update certain drivers required to connect. Keep windows 10 updated too.
Not sure what else to suggest. I've not had any issues other than an intermittent fault on one of my USB ports on an older notebook running the latest Windows 10. Anything connected drops off at random and I traced it to a bad connection since moving the connected device or cable causes Windows to respond.
Perhaps the OP wont have any issues also when he connects directly.
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