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There’s certainly a few things to consider such as osc vs mono, sensor size, QE etc - budget is probably a big factor. But as mention by others, at long fl 2 big considerations will be pixel size and fov.
In my experience with a c14 it’s good to extend your fov as much as practical with a bigger sensor, otherwise there’s going to be very limited targets you can fit in. But be careful as some reducers will significantly reduce your image circle and provide substantial vignetting on larger sensors.
CMOS cameras will usually win on QE, but don’t come with larger pixels but you can always bin. I don’t necessarily see a problem with this- just bin according to the condition or your mounts guiding accuracy.
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