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I have a 2600MM (And an MC as well)
What I have been doing with the mono is, for pure RGB images I shoot at gain 0 to get the best full well capacity, setting the exposure time the same for all RGB subs and setting it to have only a small number of saturated pixels (up to a couple of thousand, remembering that the sensor is 15 megapixels so still a really small percentage) Luminance will typically be shorter and I aim for a similar number of saturated pixels. As well as the number of saturated pixels I pay attention to the lowest values to make sure no pixels will calibrate out to black after a master dark and flat is applied. If they look like they might, I accept more saturated pixels to ensure no zero values.
For RGB-NB images where the RGB is typically just for star colours I shoot everything on gain 100 and use the same sort of values to work out the exposure times. IMO for pure LRGB, low gain produces a marginally nicer image.
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