To agree and slightly expand on how important the error is. Only you can decide if it is an issue. The only time I have found the cone error to be an issue on my Orion AZEQ6 clone was doing automated meridian flips while imaging and centering using plate solves.
I don't know about for any other software, or if it is baked in to the mount electronics, but as Gary mentioned, the direction of the error will "reverse" when you do a meridian flip. in the case of my Orion, the error led when the setup was west of the pier, pointed east for the scope to be pointed further west optically than the mount was. When the mount flipped the error was great enough that reversing it's direction would leave the scope optically pointing east of the meridian, and either in the driver or the mount firmware that leads to the plate solved sync being rejected and centering would fail. The easy solution was to image further past the meridian before flipping to ensure that the first plate solve was reliable on the west side.
If I was determined enough I could probably remove the scope mounting rings and have one machined or put a small spacer under the other to flip the error, so the scope would end up pointed further west than intended on the flip.
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