I found DSS extremely forgiving...using only light frames I have taken subs on different nights with half being "upside down" to the first batch...the overlap being so great that extreme cropping was required but DSS did not complain...I have posted this Lagoon Nebula some time ago but this was the most extreme example of subs being all over the place.
If you put dark frames in the mix I doubt if it would work however.
Slex
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