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The only time I have had a problem was when moisture in the USB-C port of my guider caused an issue, the USB-C port was (And still is) connected to the USB2 out on the ASI294, but when it messed up it took both cameras offline.
So while I have not had any real issues with cables and hubs there are certainly advantages to dedicated cables. It was a bit of messing about before I worked out the guide cam not the main cam was causing me the problem.
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