I had that discussion around the traps when I started using one. To make it even less clear the early instructions were different and I think specified east not left (Which is the same thing in the Northern hemisphere) I concluded pointing left was the way to go and stuck with that, but the only time I could see it making any difference would be if you turned on the atmospheric refraction correction (I never did) as if you had it wrong it would correct the wrong way.
By what I have seen they can be a long way off center. Mine is on axis but I have seen them on brackets mounted to the telescope dovetail bar and the EQ8 bracket looks like it places the camera a good 300mm off axis. It will introduce a little parallax but finding the center of rotation will still work fine.
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