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If you are doing a mosaic in Astro Pixel Processor, make sure you use advanced mode in the normalisation tab and local normalisation correction in the integration tab (Start with the lowest level and three iterations and see how it goes) and tick multi band blending too with the slider set to roughly the overlap percentage between frames.
Also, it is not much of an impost on registration if you only have a handful of frames and subs, but mosaic integration can be really time consuming. That one being two panels (With however many subs on each panel) don't use mosaic registration in APP. You can use normal registration so long as all frames overlap the reference frame and it is much faster to register if you have lots of subs. In theory you could register up to a 9 panel mosaic in normal registration mode (With one central frame and 8 others arranged around it, all overlapping) so long as the reference frame was one of the central ones.
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