It is not so much hot pixels Ben as random noise. If the sky gets bad enough it stretches the guider images to a high degree to try to find stars and it can try to latch on to random noise frame by frame and it can pass the minimum HFD test, the problem can come when the passing cloud (As an example) clears and PHD latches on to the wrong star.
It is probably something that would happen with more or less any guide cam and if it is a problem or not depends on how your imaging software handles it.
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