I have not so far been able to make out any rhyme or reason behind which images show severe issues and which show virtually none, not by way of what filters are in use anyway. I though the same thing as I had pretty severe reflection issues with my ASI294 until I fitted an UV-IR filter to the train, at which point they vanished.
There is a very long thread on Cloudy Nights about it and the common wisdom seems to be that it is an image of the microlenses.
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