I have found that I need to refocus occasionally during an imaging session (esp if imaging across different sections of sky in one session) - I tend to use the FWHM feature in Sharpcap and when happy then I image. I was tending to do that once at the beginning of an evening and then assuming that since I was not touching the focus tube or camera - wouldn't need to do so again that evening BUT I found that occasionally my focus looked a bit soft. My scope is a 8" F/4 though and focus is pretty fiddly at the best of times with those units.
Using the FWHM feature is a quick step to incorporate every target if needed and focus is such a critical factor in being happy with the end result so I have adapted my workflow to suit.
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