Matt,
while I have no experience with Bob's Knobs, or anyone elses knobs for that matter, I would guess at overtightening as being detrimental to your system. At worst if will cause something to break, or the thread may strip. On some secondaries there exists the possibility of "warping" the part that the screw threads fit into, and if the secondary is mounted directly, maybe it can "distort" this as well. Much like a pinched primary.
I would suggest tight, but not excessive.
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