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As Bill mentioned, I'd stack it without the flats and deal with the vignetting by cropping and see what result you get. Unfortunately if you've moved the camera or your focus, you won't be able to redo your flats as they require the image train to be in exactly the same position as shot to deal with the artifacts that were present at the time of capture. On that note I found it interesting that you used darks from a file you've created. They also have to be taken during the session because the sensor temperature is part of the cause of false pixels.
It's a great pic. Stack without flats and see how you go.
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