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What sort of camera are you using? Are you shooting the same object each night? It is likely that one set of darks and bias would be fine. Many cameras, like ASI cooled CMOS are very consistent and a dark library can be used for some time provided your optics and the camera are clean. Personally, I would stick all your lights into DSS, add a set of darks and bias (which should be shot at the same temperature as you lights if the camera is cooled). Forget the flats for now. Register and stack them in DSS then do your final processing in something like Photoshop. Forget HDR.
It can be difficult to frame each night's lights exactly the same, unless your plate solving from night to night. If your doing framing manually you may get some edge of frame overlap, rotational issues, or gaps, which can be cropped out later. DSS will certainly register and stack them. Give it a try.
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