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Hi Lee,
Do you have access to a copy of Photoshop? It does its own colour management and I think it's probably safe to assume that it will get it right (though it will depend on the monitor profile being correct...)
I get some inconsistency between screens, systems and software packages but I generally find that the same images displayed in Photoshop and PixInsight look very similar. That's on Windows but I'd hope that Mac would be the same.
You can't process "without a profile." You're probably using the monitor profile for the image colour space which is not ideal. You should have the correct monitor profile set and use a device independent profile as the default RGB profile. I mostly use AdobeRGB since it matches the gamut of my main monitor and sRGB is too limited.
Cheers,
Rick.
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