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Poor punctuation on my part. Small pixel scale is one issue and differential flexure between the two scopes is another.
With a small pixel scale, binning wont adversely affect the centroid calculation but can improve the SNR. Calibrating with very small pixels is problematic as PHD2 always moves 25 pixels. With small pixels any noise can impact the accuracy of the calibration.
In your case you'll be guiding at around 1000mm so not likely to be a problem but just something to be aware of.
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